So we're going to assume you're partly familiar with "Between Two Ferns," Zach Galifianakis's pseudo-public access show on Funny or Die featuring celebrities writhing in awkwardness while Galifianakis plays the role of the world's worst interviewer.
Our rule: the straighter the straight man, the funnier the program, so who better (or really, who more surprising) than Mr. Surly (birth name: Sean Penn) to make an appearance.
Here, our hirsute host plays Zach's effeminate brother Seth, who spends as much time convincing Penn why his dog Funions should be in the movies as asking him questions. Penn, meanwhile, hardly speaks, instead opting for the well-time grunt. Best joke: telling Penn that Seth's brother Zach wanted to say hello to his brother Ballpoint. Genius.